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José Díaz Aquino - IX Jornada Científica
Tipo de trabajo: Ponencia - Jornada de Investigación Científica
Correo: josediazaquino@yahoo.com

Trabajos publicados:

DENGUE, Actualización ¿Qué hay de nuevo?

RESUMEN: El dengue es una enfermedad infecciosa, de etiología viral, sistémica y dinámica. Siendo la enfermedad que más ha aumentado en términos de incidencia. El objetivo es presentar una actualización en prevención de dengue y los beneficios de las vacunas de dengue. Se realizó revisión bibliográfica de artículos recientes sobre dengue y su incidencia, y documentos publicados por la Organización Mundial de la Salud. Encontramos las pruebas utilizadas para Aislamiento del virus, detección de antígeno NS1, detección de anticuerpos (IgG, IgM), detección del genoma del virus (RT-PCR). La DengVaxia® es una Vacuna tetravalente atenuada, combina el esqueleto gené-tico del virus de la fiebre amarilla con antígenos proteicos (PrM) y Envoltura (E) de los 4 serotipos del DENV, tiene una eficacia de 80%. QDenga® es una Vacuna tetravalente, atenuada, compues-ta por una cepa de DENV-2 y tres virus quiméricos a los que se les inserta, la proteína M, las pro-teínas de envoltura (E) del (DENV-1, DENV-3, DENV-4). La eficacia de la inmunización fue del 80,2 %. En enero, 2024, Brasil publico los resultados de Butantan-DV® otra vacuna atenuada te-travalente, compuesta por virus atenuados (DENV-1, DENV-3, DENV-4) y un virus quimérico (DENV-2). En conclusión, existen medidas preventivas que han sido efectivas, los casos de den-gue siguen en aumento, debido a las condiciones climáticas y fenómenos naturales. No podemos perder tiempo, con relación a la prevención de nuestra población. Necesitamos de forma urgente la vacuna.

Palabras Clave:
Dengue, Antígeno NS1, Vacunas, DengVaxia®, QDenga®, Butantan-DV®.

 

 

ABSTRACT: Dengue is an infectious disease, with viral, systemic and dynamic etiology. Being the disease that has increased the most in terms of incidence. The objective of the study is to pre-sent an update on dengue prevention and the benefits of dengue vaccines. A bibliographic review of recent articles on dengue and its incidence, and documents published by the World Health Or-ganization, was carried out. We find the tests used for virus isolation, detection of NS1 antigen, detection of antibodies (IgG, IgM), detection of the virus genome (RT-PCR). DengVaxia® is an attenuated tetravalent vaccine, it combines the genetic skeleton of the yellow fever virus with pro-tein antigens (PrM) and envelope (E) of the 4 DENV serotypes, it has an efficacy of 80%. QDenga® is a tetravalent, attenuated vaccine, composed of a strain of DENV-2 and three chimer-ic viruses to which the M protein, the envelope (E) proteins of (DENV-1, DENV-3, DENV -4). The immunization efficiency was 80.2%. In January 2024, Brazil published the results of Bu-tantan-DV® another tetravalent attenuated vaccine, composed of attenuated viruses (DENV-1, DENV-3, DENV-4) and a chimeric virus (DENV-2). In conclusion, there are preventive measures that have been effective, dengue cases continue to increase, due to climatic conditions and natural phenomena. We cannot waste time, in relation to the prevention of our population. We urgently need the vaccine.

Keywords:
Dengue, NS1 Antigen, Vaccines, DengVaxia®, QDenga®, Butantan-DV®.

Documento Adjunto
Autores:
  • José Díaz Aquino
  • Mildre Disla Meléndez
  • Modesto Cruz Lluberes